Predictive Value of Serum Lipid for Intravenous Immunoglobulin Resistance and Coronary Artery Lesion in Kawasaki Disease

Abstract Context Intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) prediction are pivotal topic of interests in Kawasaki disease (KD). However, data on the predictive value lipid profile for both IVIG CALs limited. Purpose To investigate validity KD. Design Prospective cohort study. Setting West China Second University Hospital. Patients 363 KD patients were divided into initial IVIG-resistant group IVIG-responsive group; repeated CAL+ CAL− group. Main Outcome Measures Validity predicting CALs. Results Triglycerides significantly higher whereas total cholesterol (TC), high-densisty lipoprotein (HDL-C), low-density (LDL-C), apolipoprotein A (Apo A) lower subjects, with cut-off values 1.625 mmol/L, 3.255 0.475 1.965 0.665 g/L, yielding sensitivities 52%, 70%, 61%, 50% specificities 68%, 53%, 78%, 71%, 81%, respectively. TC, LDL-C, Apo levels 3.20 1.78 0.605 producing 91%, 57% 55%, 67%, level was group, 0.805 sensitivity 66% specificity 54%. Conclusions Lipid profiles dysregulated suffering Some them, such as LDL-C A, could serve complementary laboratory markers